Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study.
Identifieur interne : 001A37 ( Main/Exploration ); précédent : 001A36; suivant : 001A38Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study.
Auteurs : Renee W Y. Chan [République populaire de Chine] ; Maged G. Hemida [Égypte] ; Ghazi Kayali [États-Unis] ; Daniel K W. Chu [République populaire de Chine] ; Leo L M. Poon [République populaire de Chine] ; Abdelmohsen Alnaeem [Arabie saoudite] ; Mohamed A. Ali [Égypte] ; Kin P. Tao [République populaire de Chine] ; Hoi Y. Ng [République populaire de Chine] ; Michael C W. Chan [République populaire de Chine] ; Yi Guan [République populaire de Chine] ; John M. Nicholls [République populaire de Chine] ; J S Malik Peiris [République populaire de Chine]Source :
- The Lancet. Respiratory medicine [ 2213-2619 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Appareil respiratoire, Infections à coronavirus.
- Animaux, Arabie saoudite, Chameaux, Humains, Réplication virale, Tropisme viral, Égypte.
English descriptors
- KwdEn :
- MESH :
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Respiratory System.
- Animals, Camelus, Egypt, Humans, Saudi Arabia, Viral Tropism, Virus Replication.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic infection causing severe viral pneumonia, with index cases having resided in or recently travelled to the Arabian peninsula, and is a global concern for public health. Limited human-to-human transmission, leading to some case clusters, has been reported. MERS-CoV has been reported in dromedary camels but phenotypic characterisation of such viruses is limited. We aimed to compare MERS-CoV isolates from dromedaries in Saudi Arabia and Egypt with a prototype human MERS-CoV to assess virus replication competence and cell tropism in ex-vivo cultures of human bronchus and lung.
DOI: 10.1016/S2213-2600(14)70158-4
PubMed: 25174549
Affiliations:
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Ali</name><affiliation wicri:level="1"><nlm:affiliation>Center of Excellence for Influenza Viruses, National Research Center, Giza, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Center of Excellence for Influenza Viruses, National Research Center, Giza</wicri:regionArea><wicri:noRegion>Giza</wicri:noRegion></affiliation></author><author><name sortKey="Tao, Kin P" sort="Tao, Kin P" uniqKey="Tao K" first="Kin P" last="Tao">Kin P. 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Nicholls</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. Electronic address: nicholls@pathology.hku.hk.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J S Malik" last="Peiris">J S Malik Peiris</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. Electronic address: malik@hku.hk.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25174549</idno><idno type="pmid">25174549</idno><idno type="doi">10.1016/S2213-2600(14)70158-4</idno><idno type="wicri:Area/PubMed/Corpus">001862</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001862</idno><idno type="wicri:Area/PubMed/Curation">001862</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001862</idno><idno type="wicri:Area/PubMed/Checkpoint">001697</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001697</idno><idno type="wicri:Area/Ncbi/Merge">000E86</idno><idno type="wicri:Area/Ncbi/Curation">000E86</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E86</idno><idno type="wicri:Area/Main/Merge">001A42</idno><idno type="wicri:Area/Main/Curation">001A37</idno><idno type="wicri:Area/Main/Exploration">001A37</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study.</title><author><name sortKey="Chan, Renee W Y" sort="Chan, Renee W Y" uniqKey="Chan R" first="Renee W Y" last="Chan">Renee W Y. Chan</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Hemida, Maged G" sort="Hemida, Maged G" uniqKey="Hemida M" first="Maged G" last="Hemida">Maged G. Hemida</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Saudi Arabia; Department of Virology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Saudi Arabia; Department of Virology, Faculty of Veterinary Medicine, Kafrelsheikh University</wicri:regionArea><wicri:noRegion>Kafrelsheikh University</wicri:noRegion></affiliation></author><author><name sortKey="Kayali, Ghazi" sort="Kayali, Ghazi" uniqKey="Kayali G" first="Ghazi" last="Kayali">Ghazi Kayali</name><affiliation wicri:level="2"><nlm:affiliation>Division of Virology, Department of Infectious Diseases, St Jude Children's Hospital, Memphis, TN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Virology, Department of Infectious Diseases, St Jude Children's Hospital, Memphis, TN</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Chu, Daniel K W" sort="Chu, Daniel K W" uniqKey="Chu D" first="Daniel K W" last="Chu">Daniel K W. Chu</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. Poon</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Alnaeem, Abdelmohsen" sort="Alnaeem, Abdelmohsen" uniqKey="Alnaeem A" first="Abdelmohsen" last="Alnaeem">Abdelmohsen Alnaeem</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Studies, College of Veterinary Medicine, King Faisal University, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Clinical Studies, College of Veterinary Medicine, King Faisal University</wicri:regionArea><wicri:noRegion>King Faisal University</wicri:noRegion></affiliation></author><author><name sortKey="Ali, Mohamed A" sort="Ali, Mohamed A" uniqKey="Ali M" first="Mohamed A" last="Ali">Mohamed A. Ali</name><affiliation wicri:level="1"><nlm:affiliation>Center of Excellence for Influenza Viruses, National Research Center, Giza, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Center of Excellence for Influenza Viruses, National Research Center, Giza</wicri:regionArea><wicri:noRegion>Giza</wicri:noRegion></affiliation></author><author><name sortKey="Tao, Kin P" sort="Tao, Kin P" uniqKey="Tao K" first="Kin P" last="Tao">Kin P. Tao</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Hoi Y" sort="Ng, Hoi Y" uniqKey="Ng H" first="Hoi Y" last="Ng">Hoi Y. Ng</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Michael C W" sort="Chan, Michael C W" uniqKey="Chan M" first="Michael C W" last="Chan">Michael C W. Chan</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M" last="Nicholls">John M. Nicholls</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. Electronic address: nicholls@pathology.hku.hk.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J S Malik" last="Peiris">J S Malik Peiris</name><affiliation wicri:level="1"><nlm:affiliation>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. Electronic address: malik@hku.hk.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre of Influenza Research and School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China; State Key Laboratory of Emerging Infectious Disease, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Lancet. Respiratory medicine</title><idno type="eISSN">2213-2619</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Camelus</term><term>Coronavirus Infections (virology)</term><term>Egypt</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Respiratory System (virology)</term><term>Saudi Arabia</term><term>Viral Tropism</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Appareil respiratoire (virologie)</term><term>Arabie saoudite</term><term>Chameaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Humains</term><term>Infections à coronavirus (virologie)</term><term>Réplication virale</term><term>Tropisme viral</term><term>Égypte</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Camelus</term><term>Egypt</term><term>Humans</term><term>Saudi Arabia</term><term>Viral Tropism</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Arabie saoudite</term><term>Chameaux</term><term>Humains</term><term>Réplication virale</term><term>Tropisme viral</term><term>Égypte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic infection causing severe viral pneumonia, with index cases having resided in or recently travelled to the Arabian peninsula, and is a global concern for public health. Limited human-to-human transmission, leading to some case clusters, has been reported. MERS-CoV has been reported in dromedary camels but phenotypic characterisation of such viruses is limited. We aimed to compare MERS-CoV isolates from dromedaries in Saudi Arabia and Egypt with a prototype human MERS-CoV to assess virus replication competence and cell tropism in ex-vivo cultures of human bronchus and lung.</div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>République populaire de Chine</li><li>Égypte</li><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Chan, Renee W Y" sort="Chan, Renee W Y" uniqKey="Chan R" first="Renee W Y" last="Chan">Renee W Y. Chan</name></noRegion><name sortKey="Chan, Michael C W" sort="Chan, Michael C W" uniqKey="Chan M" first="Michael C W" last="Chan">Michael C W. Chan</name><name sortKey="Chu, Daniel K W" sort="Chu, Daniel K W" uniqKey="Chu D" first="Daniel K W" last="Chu">Daniel K W. Chu</name><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name><name sortKey="Ng, Hoi Y" sort="Ng, Hoi Y" uniqKey="Ng H" first="Hoi Y" last="Ng">Hoi Y. Ng</name><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M" last="Nicholls">John M. Nicholls</name><name sortKey="Peiris, J S Malik" sort="Peiris, J S Malik" uniqKey="Peiris J" first="J S Malik" last="Peiris">J S Malik Peiris</name><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. Poon</name><name sortKey="Tao, Kin P" sort="Tao, Kin P" uniqKey="Tao K" first="Kin P" last="Tao">Kin P. Tao</name></country><country name="Égypte"><noRegion><name sortKey="Hemida, Maged G" sort="Hemida, Maged G" uniqKey="Hemida M" first="Maged G" last="Hemida">Maged G. Hemida</name></noRegion><name sortKey="Ali, Mohamed A" sort="Ali, Mohamed A" uniqKey="Ali M" first="Mohamed A" last="Ali">Mohamed A. Ali</name></country><country name="États-Unis"><region name="Tennessee"><name sortKey="Kayali, Ghazi" sort="Kayali, Ghazi" uniqKey="Kayali G" first="Ghazi" last="Kayali">Ghazi Kayali</name></region></country><country name="Arabie saoudite"><noRegion><name sortKey="Alnaeem, Abdelmohsen" sort="Alnaeem, Abdelmohsen" uniqKey="Alnaeem A" first="Abdelmohsen" last="Alnaeem">Abdelmohsen Alnaeem</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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